The label says, word for word:
Temaril-P is recommended for the relief of itching regardless of cause. Its usefulness has been demonstrated for the relief of itching and the reduction of inflammation commonly associated with most skin disorders of dogs such as the eczema caused by internal disorders, otitis, and dermatitis (allergic, parasitic, pustular, and nonspecific).
Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis.
Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring.
Cushings syndrome in dogs has been reported in association with prolonged or repeated steroid therapy.
Possible increased susceptibility to bacterial invasion and/or the exacerbation of preexisting bacterial infection may occur in patients receiving corticosteroids.
Prolonged treatment with Temaril-P must be withdrawn gradually.
Every approved medicine has a field study behind it, and the label prints what happened:
Possible side effects attributable to corticosteroids include sodium retention and potassium loss, negative nitrogen balance, suppressed adrenal cortical function, delayed wound healing, osteoporosis, elevated levels of SGPT and SAP, and vomiting and diarrhea (occasionally bloody).
An older combination product (antihistamine/phenothiazine plus corticosteroid); the label has no Contraindications section, no Human Warnings, no Client Information Sheet and no field-study adverse-reaction table; side effects are listed in a section titled "PRECAUTIONS AND SIDE EFFECTS". Other label statements owners should know: "All the precautions applicable to cortisone and to phenothiazine derivatives apply also to Temaril-P." "Therefore, the veterinarians must be alert to detect less obvious side effects, such as blood dyscrasias, polydipsia, and polyuria."
The emergency page sorts the signs by how long you have, and the symptom checker asks what you are seeing. Reactions to a medicine can also be reported to the FDA yourself: how to report a problem.
These answers come from the approved label on DailyMed, read on 2 October 2026. Where the label does not say, the answer says so, and the vet or the pharmacist is the one to ask.
The approved use is quoted at the top of this page. It is a tablet given to dogs to relieve itching and to reduce the inflammation that comes with most skin disorders, and the label also recommends it for certain coughs, kennel cough among them. It combines trimeprazine, which the label says acts against itch and cough, with prednisolone, a steroid that acts against inflammation.
The label gives no time. Ask the vet what to expect and by when.
It is a tablet given by mouth, and the label's schedule is twice a day. After 4 days the label has the starting amount reduced, down to the least that keeps the signs away, and it says the amount should be adjusted to how each dog responds, so the vet sets both. The label does not say whether to give it with food. It does say that prolonged treatment must be withdrawn gradually, so after a long course do not stop it suddenly without a plan from the vet.
The label does not say what to do about a missed dose. Call the clinic or the pharmacy before you give the next one.
The studies and the warnings are quoted above. The label says that if troublesome side effects appear, the amount should be reduced and the drug stopped, unless the condition being treated is severe enough that relieving it matters more. That decision is the vet's, and because long treatment has to be withdrawn gradually, call the vet instead of stopping it yourself. The side effects the label names include sleepiness, drinking and urinating more than usual, and vomiting or diarrhea, sometimes with blood.
The label says to store it in a dry, cool place at temperatures not above 77°F.
The FDA says the best way to get rid of most unused or expired medicines is a take-back option: a drug take-back location, which can be at a pharmacy or a police station, or a prepaid mail-back envelope. If you cannot use one and the medicine is not on the FDA's flush list, the FDA says to mix it, uncrushed, with something unappealing such as dirt, cat litter or used coffee grounds and to seal the mixture in a plastic bag before throwing it away. Flushing is only for medicines on that list, such as opioids. Do not give leftovers to another pet.
Write the dose, the times and the stop date here, then print this page for the fridge.
Dose and times: _____________________________________________
Stop date: _____________________________________________