The label says, word for word:
SOLENSIA is indicated for the control of pain associated with osteoarthritis in cats.
SOLENSIA should not be administered to cats with known hypersensitivity to frunevetmab.
SOLENSIA should not be used in breeding cats or in pregnant or lactating queens because it may pass through the placental blood barrier and be excreted in milk.
Not for use in humans. Keep out of reach of children. Hypersensitivity reactions, including anaphylaxis, could potentially occur in the case of accidental self-injection.
Pregnant women, women trying to conceive, and breastfeeding women should take extreme care to avoid accidental self-injection.
SOLENSIA has not been evaluated in cats less than 7 months or 5.5 lbs.
The safe use of SOLENSIA with concurrent non-steroidal anti-inflammatory drugs (NSAIDs) has not been established in cats.
Administration of SOLENSIA may be associated with scabbing on the head and neck, dermatitis, and pruritus; however, preapproval data suggest that these signs do not require cessation of SOLENSIA administration (see ADVERSE REACTIONS and TARGET ANIMAL SAFETY).
Every approved medicine has a field study behind it, and the label prints what happened:
Field study 1 (SOLENSIA n=182 vs vehicle control n=93): Vomiting 24 (13.2%) vs 10 (10.8%); Injection site pain 20 (10.9%) vs 13 (14%); Diarrhea 12 (6.6%) vs 5 (5.4%); Abnormal behavior and behavioral disorders 12 (6.6%) vs 5 (5.4%); Renal insufficiency 12 (6.6%) vs 4 (4.3%); Anorexia 12 (6.6%) vs 4 (4.3%); Lethargy 11 (6.0%) vs 3 (3.2%); Dermatitis 11 (6.0%) vs 1 (1.1%); Alopecia 10 (5.5%) vs 2 (2.2%);…
First monoclonal antibody drug approved by FDA for any animal species (FDA FOI summary: Date of Approval January 13, 2022, NADA 141-546, Zoetis Inc.). Given by the veterinarian as a subcutaneous injection. The label has no Client Information Sheet, no 'Information for Cat Owners' section and no Post-Approval Experience section. Other precautions: "Long term effects, which may occur more than 6 months after the use of SOLENSIA, have not been evaluated." "Treatment with SOLENSIA may result in the formation of anti-frunevetmab antibodies and potentially the loss of product effectiveness."
The emergency page sorts the signs by how long you have, and the symptom checker asks what you are seeing. Reactions to a medicine can also be reported to the FDA yourself: how to report a problem.
These answers come from the approved label on DailyMed, read on 2 October 2026. Where the label does not say, the answer says so, and the vet or the pharmacist is the one to ask.
The approved use is quoted at the top of this page. It is an injection given to cats once a month to control the pain of osteoarthritis.
The label does not say when an owner should expect to see a change. In its 112-day field study the first check came 28 days after the first injection, and at that check 66.9% of the cats given Solensia counted as a success on their owners' scoring, against 51.6% of the cats given an injection without the drug. The label also says the drug reaches a steady level in the body after about two doses, which are given a month apart.
It is an injection under the skin, given once a month. The label has no instructions for owners giving it at home, so ask the clinic who gives it. The vet works out the amount from the cat's weight. The label says the product contains no preservative, that each vial is for a single use, and that the contents are used straight away once the vial has been punctured.
The label does not say what to do about a missed dose. Call the clinic and ask when the next injection should be.
The studies and the warnings are quoted above. The label has no line telling owners when to call the vet. It says that if an allergic reaction occurs, including a severe one, the drug is stopped and the cat is treated. The reactions recorded most often in its field study were vomiting, pain where the injection went in, diarrhea, changes in behavior, kidney trouble, eating less, low energy, skin inflammation and hair loss. The label also describes scabbing on the head and neck and itching. If you see any of these after an injection, or your cat seems unwell, call the vet.
The label has the vials stored upright in a refrigerator, between 35° and 46°F. They must not be frozen, and they are protected from light. Keep them out of the reach of children.
The label says each vial is for a single use and that anything left in a punctured vial is discarded, so there should be nothing left over from an injection. For the other medicines in the house, the FDA's advice is as follows. The FDA says the best way to get rid of most unused or expired medicines is a take-back option: a drug take-back location, which can be at a pharmacy or a police station, or a prepaid mail-back envelope. If you cannot use one and the medicine is not on the FDA's flush list, the FDA says to mix it, uncrushed, with something unappealing such as dirt, cat litter or used coffee grounds and to seal the mixture in a plastic bag before throwing it away. Flushing is only for medicines on that list, such as opioids. Do not give leftovers to another pet.
Write the dose, the times and the stop date here, then print this page for the fridge.
Dose and times: _____________________________________________
Stop date: _____________________________________________