The label says, word for word:
LIBRELA is indicated for the control of pain associated with osteoarthritis in dogs.
LIBRELA should not be administered to dogs with known hypersensitivity to bedinvetmab.
LIBRELA should not be used in breeding dogs or in pregnant or lactating dogs.
Not for use in humans. Keep this and all drugs out of reach of children. For use in dogs only.
Hypersensitivity reactions, including anaphylaxis, could potentially occur in case of accidental self-injection.
Pregnant women, women trying to conceive, and breastfeeding women should take extreme care to avoid accidental self-injection.
The safety and effectiveness of LIBRELA has not been evaluated in dogs less than 12 months of age.
The safe use of anti-NGF monoclonal antibodies with concurrent nonsteroidal anti-inflammatory drugs (NSAIDs) has not been established in dogs.
Every approved medicine has a field study behind it, and the label prints what happened:
US field study (LIBRELA n=135 vs control n=137): Urinary tract infection 15 (11.1%) vs 11 (8.0%); Bacterial skin infection 11 (8.1%) vs 9 (6.6%); Dermatitis 10 (7.4%) vs 8 (5.8%); Dermal mass 8 (5.9%) vs 5 (3.6%); Pain on injection 4 (3.0%) vs 2 (1.5%); Inappropriate urination 4 (3.0%) vs 1 (0.7%).
From the sheet the maker writes for owners:
First monoclonal antibody approved by FDA for dogs (FDA CVM Update, May 5, 2023: "Today, the U.S. Food and Drug Administration approved Librela (bedinvetmab injection)"). FDA FOI summary: Date of Approval May 5, 2023, NADA 141-562, Zoetis Inc. Given by the veterinarian as a subcutaneous injection. Label precautions also state: "Long term effects which may occur more than 9 months after the use of LIBRELA have not been evaluated." and "NGF is expressed within the heart and vasculature, and the long-term effects of reduced NGF in dogs with cardiac disease are unknown."
The emergency page sorts the signs by how long you have, and the symptom checker asks what you are seeing. Reactions to a medicine can also be reported to the FDA yourself: how to report a problem.
These answers come from the approved label on DailyMed, read on 2 October 2026. Where the label does not say, the answer says so, and the vet or the pharmacist is the one to ask.
The approved use is quoted at the top of this page. It is given to dogs to control the pain of osteoarthritis.
The label says the effect may not be reached until after the second dose. The doses are given a month apart.
You do not give it yourself. It is an injection under the skin that the vet gives once a month, and the instructions on the label are written for the vet. The label tells the vet to give you the Client Information Sheet and to talk through the possible side effects with you before each injection.
The label does not say what to do about a missed dose. Call the clinic and ask when the next injection should be.
The studies and the warnings are quoted above. The label tells vets to advise owners to contact them if they see balance problems, trouble walking, weakness, trouble standing, seizures, drinking more, urinating more, loss of bladder control, vomiting or diarrhea, or any other sign of illness. It says serious reactions can occur and can end in death or euthanasia. It also says that a dog that could not exercise before treatment is at greater risk of injury if it becomes more active afterwards, and it tells the vet to discuss an exercise plan with the owner.
The storage rules on the label are for the vet, who handles the vials. The vials are kept in a refrigerator at 36° to 46°F, must not be frozen, and stay in their boxes to protect them from long exposure to light.
There should be no leftovers of this medicine at home: the vet gives the injection, and the label says each vial is for a single use and anything left in it after opening is discarded. For the other medicines in the house, the FDA says the best way to get rid of most unused or expired ones is a take-back option: a drug take-back location, which can be at a pharmacy or a police station, or a prepaid mail-back envelope. If you cannot use one, the FDA says a medicine that is not on its flush list can go in the trash at home. Its steps are to mix the medicine with something unappealing such as dirt, cat litter or used coffee grounds, without crushing it, and to seal the mixture in a plastic bag before throwing it away. Flushing is only for medicines on that list, such as opioids. Do not give leftovers to another pet.
Write the dose, the times and the stop date here, then print this page for the fridge.
Dose and times: _____________________________________________
Stop date: _____________________________________________