The label says, word for word:
GALLIPRANT (grapiprant tablets) is indicated for the control of pain and inflammation associated with osteoarthritis in dogs.
GALLIPRANT should not be used in dogs that have a hypersensitivity to grapiprant.
Not for use in humans. Keep this and all medications out of reach of children and pets. Consult a physician in case of accidental ingestion by humans. For use in dogs only.
Do not administer GALLIPRANT in conjunction with any other oral or injectable NSAID or corticosteroid.
Keep GALLIPRANT in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.
The safe use of GALLIPRANT has not been evaluated in dogs younger than 9 months of age and less than 8 lbs (3.6 kgs), dogs used for breeding, or in pregnant or lactating dogs.
The use of GALLIPRANT in dogs with cardiac disease has not been studied.
Every approved medicine has a field study behind it, and the label prints what happened:
Controlled field study table (GALLIPRANT N=141 vs vehicle control N=144; no percentages printed): Vomiting 24 vs 9; Diarrhea, soft stool 17 vs 13; Anorexia, inappetence 9 vs 7; Lethargy 6 vs 2; Buccal ulcer 1 vs 0; Immune mediated hemolytic anemia 1 vs 0. Post-approval: "The following adverse events are based on post-approval adverse drug experience reporting for GALLIPRANT in decreasing order by frequency."
From the sheet the maker writes for owners:
Label description: "GALLIPRANT (grapiprant tablets) is a prostaglandin E2 (PGE2) EP4 receptor antagonist; a non-cyclooxygenase (COX) inhibiting, non-steroidal anti-inflammatory drug (NSAID) in the piprant class." Owner sheet: "Serious adverse reactions associated with this drug class can occur without warning and, in some cases, result in death." Original approval (FDA FOI summary): Date of Approval March 20, 2016, NADA 141-455, sponsor Aratana Therapeutics, Inc.; the current label is Elanco's. Label revision on DailyMed: October 2024.
The emergency page sorts the signs by how long you have, and the symptom checker asks what you are seeing. Reactions to a medicine can also be reported to the FDA yourself: how to report a problem.
These answers come from the approved label on DailyMed, read on 2 October 2026. Where the label does not say, the answer says so, and the vet or the pharmacist is the one to ask.
The approved use is quoted at the top of this page. It is a tablet for dogs that controls the pain and inflammation of osteoarthritis. The owner sheet on the label describes it as a non-steroidal anti-inflammatory drug, an NSAID.
The label gives no time for when a dog should seem more comfortable. It says the drug is absorbed rapidly, with the level in the blood peaking within about 2 hours of a tablet. The owner sheet says that control of pain and inflammation may vary from dog to dog. Ask the vet what to expect and by when.
It is a tablet given by mouth once a day. The label does not say whether to give it with food. Its pharmacology section reports that taking the tablet with food cut the peak level of the drug in the blood to about a quarter, so ask the vet whether to give it on an empty stomach. The two smaller tablet sizes are scored for halving, and the label says the largest tablet should not be broken in half. The label tells vets to use the lowest dose that works for the shortest time that fits the dog's response. The owner sheet says Galliprant should only be given to dogs and should not be used in cats.
The label does not say what to do about a missed dose. Call the clinic or the pharmacy before you give the next one.
The studies and the warnings are quoted above. The owner sheet on the label says it is important to stop the medication and contact the vet immediately if you think your dog has a medical problem or a side effect while on Galliprant. The signs it lists are diarrhea, soft or slimy stool, black, tarry or bloody stool, vomiting, eating less, a change in behavior such as depression or restlessness, loss of coordination or seizures, a change in drinking or urination, and yellowing of the gums, the skin or the whites of the eyes. It also says to contact the vet immediately if your dog eats more than the prescribed amount, and that Galliprant should not be given with aspirin, other NSAIDs or corticosteroids.
Store it at or below 86°F. The label says to keep it out of the reach of children and pets. It also says to keep it in a secure place out of reach of dogs, cats and other animals, to prevent accidental swallowing or an overdose.
The FDA says the best way to get rid of most unused or expired medicines is a take-back option: a drug take-back location, which can be at a pharmacy or a police station, or a prepaid mail-back envelope. If you cannot use one and the medicine is not on the FDA's flush list, the FDA says to mix it, uncrushed, with something unappealing such as dirt, cat litter or used coffee grounds and to seal the mixture in a plastic bag before throwing it away. Flushing is only for medicines on that list, such as opioids. Do not give leftovers to another pet. The owner sheet on the label makes the same point: Galliprant should only be given to the dog it was prescribed for.
Write the dose, the times and the stop date here, then print this page for the fridge.
Dose and times: _____________________________________________
Stop date: _____________________________________________