The label says, word for word:
CLOMICALM tablets are to be used as part of a comprehensive behavioral management program to treat separation anxiety in dogs greater than 6 months of age. Inappropriate barking or destructive behavior, as well as inappropriate elimination (urination or defecation) may be alleviated by the use of CLOMICALM tablets in conjunction with behavior modification.
CLOMICALM tablets are contraindicated in dogs with known hypersensitivity to clomipramine or other tricyclic antidepressants. CLOMICALM tablets should not be used in male breeding dogs. CLOMICALM tablets should not be given in combination, or within 14 days before or after treatment with a monoamine oxidase inhibitor [e.g., selegiline hydrochloride (L-deprenyl), amitraz].
Not for use in humans. Keep out of reach of children. In case of accidental ingestion seek medical attention immediately. In children, accidental ingestion should be regarded as serious.
CLOMICALM tablets are contraindicated for use in dogs with a history of seizures or concomitantly with drugs which lower the seizure threshold.
CLOMICALM tablets are not recommended for other behavior problems, such as aggression.
Studies to establish the safety and efficacy of CLOMICALM tablets in dogs less than 6 months of age have not been conducted. Safety studies to determine the effects of CLOMICALM tablets in pregnant or lactating female dogs have not been conducted.
Use with caution in dogs with cardiovascular disease. Caution is advised in using clomipramine with anticholinergic or sympathomimetic drugs or with other CNS-active drugs.
Every approved medicine has a field study behind it, and the label prints what happened:
Label: "Frequency and category of adverse reactions observed in dogs dosed with CLOMICALM tablets or placebo were observed in multisite clinical studies."
From the sheet the maker writes for owners:
Approved by FDA under NADA # 141-120. The research list named Elanco as maker, but the current DailyMed label reads "Manufactured by: Virbac AH, Inc." and the FDA Green Book lists NADA 141-120 CLOMICALM / Virbac AH, Inc.; the original sponsor in the FDA Freedom of Information Summary was "Novartis Animal Health US, Inc." A supplemental FOI summary (November 22, 2006, adding a tablet size) states: "The FOI Summary for the original approval of NADA 141-120 dated December 10, 1998 contains dosage characterization information for dogs at the approved label dose." - hence approved_year 1998.
The emergency page sorts the signs by how long you have, and the symptom checker asks what you are seeing. Reactions to a medicine can also be reported to the FDA yourself: how to report a problem.
These answers come from the approved label on DailyMed, read on 2 October 2026. Where the label does not say, the answer says so, and the vet or the pharmacist is the one to ask.
The approved use is quoted at the top of this page. It is a tablet for dogs older than six months with separation anxiety, and the label approves it only as one part of a behavior training program.
The label gives no fixed time. One of its studies ran for eight weeks. After one week, 47% of the dogs given Clomicalm together with behavior training had improved, against 29% of the dogs given the training alone. The owner section of the label adds that the tablets do not act as a sedative.
It is a tablet given by mouth. The label says the vet will tell you whether to give it once a day or to split the day's amount into two. It says the tablet may be given with a small amount of food to make vomiting less likely. When the time comes to stop, the label recommends lowering the dose step by step while the vet keeps watch, and it says the behavior training should carry on. Use for longer than 12 weeks was not evaluated for the label.
The label says that if a dose is missed, the next one should be given at the next scheduled time, without doubling it.
The studies and the warnings are quoted above. The owner section says to tell your vet about any change you notice in your dog's behavior, appetite or overall health. It says some dogs are lethargic for the first few days, and that signs of separation anxiety such as barking or howling may get worse for a while at the start. It also says to get the dog to a vet as soon as possible after an overdose. The signs of an overdose it lists are vomiting, lethargy, weakness, unsteadiness, wide pupils and crying out.
The label says to store the tablets in a dry place at room temperature, between 59° and 77°F, and to keep unused tablets in the original closed container. It also says to keep them out of reach of children.
The FDA says the best way to get rid of most unused or expired medicines is a take-back option: a drug take-back location, which can be at a pharmacy or a police station, or a prepaid mail-back envelope. If you cannot use one and the medicine is not on the FDA's flush list, the FDA says to mix it, uncrushed, with something unappealing such as dirt, cat litter or used coffee grounds and to seal the mixture in a plastic bag before throwing it away. Flushing is only for medicines on that list, such as opioids. Do not give leftovers to another pet.
Write the dose, the times and the stop date here, then print this page for the fridge.
Dose and times: _____________________________________________
Stop date: _____________________________________________