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What is Benazepril?

Benazepril (benazepril hydrochloride). A human medicine with no animal label. What that means for your pet.

dogsFor
tabletForm
prescriptionHow you get it
1991FDA approved
Validus Pharmaceuticals LLC (Lotensin, human label)Label holder
There is no animal label for this one.

It is a human medicine. A vet may still prescribe it for a dog or cat, which is legal and common, but it means no company has proved to the FDA that it works or is safe in that animal, and there is no approved animal dose to look up. Ask your vet what they expect it to do and what to watch for.

What it is approved for

The label says, word for word:

Human label (Lotensin): "Lotensin is indicated for the treatment of hypertension, to lower blood pressure." There is no US animal label for benazepril alone; Fortekor is not FDA-approved. Benazepril is FDA-approved for dogs only in a fixed combination with spironolactone (Cardalis).

When it must not be used

Lotensin is contraindicated in patients: who are hypersensitive to benazepril or to any other ACE inhibitor; with a history of angioedema with or without previous ACE inhibitor treatment.

What the label warns about

WARNING: FETAL TOXICITY. When pregnancy is detected, discontinue Lotensin as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
Angioedema of the face, extremities, lips, tongue, glottis, and/or larynx including some fatal reactions, have occurred.
Lotensin can cause symptomatic hypotension, sometimes complicated by oliguria, progressive azotemia, acute renal failure, or death.
Monitor renal function periodically in patients treated with Lotensin.
Serum potassium should be monitored periodically in patients receiving Lotensin.

What turned up in the studies

Every approved medicine has a field study behind it, and the label prints what happened:

Human label: "Adverse reactions seen in at least 1% greater frequency in patients treated with Lotensin than placebo were headache (6% vs. 4%), dizziness (4% vs. 2%), somnolence (2% vs. 0%) and postural dizziness (2% vs. 0%)."

Worth knowing

No US veterinary approval for benazepril alone: a DailyMed search for "fortekor" returns "No Drug Package Labels found." and no FDA approval of a benazepril-only animal drug was found on fda.gov or animaldrugsatfda.fda.gov. Veterinarians may prescribe the human drug extra-label under AMDUCA (https://www.fda.gov/animal-veterinary/resources-you/ins-and-outs-extra-label-drug-use-animals-resource-veterinarians).

What to ask your vet

No doses on this page, on purpose. The dose depends on the animal's weight, age, kidneys, liver and everything else they take. That is the vet's job. The human label is linked below. Never start, stop or change a medication on your own.
Not sure it can wait?

The emergency page sorts the signs by how long you have, and the symptom checker asks what you are seeing. Reactions to a medicine can also be reported to the FDA yourself: how to report a problem.

Everyday questions, answered from the paperwork

These answers come from the approved label on DailyMed, read on 2 October 2026. Where the label does not say, the answer says so, and the vet or the pharmacist is the one to ask.

What is it for?

The approved use is quoted at the top of this page. The label read for these answers is the one for Lotensin, the benazepril tablet made for people, and its approved use is high blood pressure in people. It gives no instructions for a dog or a cat, so for a pet every answer below comes back to the vet who prescribed it. If your pet's tablets are not Lotensin, go by the leaflet and the pharmacy label that came with them. Cardalis, a chewable tablet for dogs that contains benazepril together with spironolactone, has a label of its own.

How soon does it work?

The label gives no time for a pet. In people, it says a single dose lowered blood pressure within one hour, with the largest drop between two and four hours after the tablet. Ask the vet what to expect and by when.

How do I give it?

It is a tablet given by mouth. The label gives doses for people only, so the amount and the timing for your pet come from the vet. Its dosing section does not say whether to take the tablet with food. Elsewhere the label says food does not change how much of the drug is absorbed, only how soon it peaks.

What if I miss a dose?

The label does not say what to do about a missed dose. Call the clinic or the pharmacy before you give the next one.

What side effects should I watch for?

The studies and the warnings are quoted above. The warning signs on this label are written for people. It tells patients to report swelling of the face, eyes, lips or tongue, or trouble breathing, at once and to take no more until they have spoken to the doctor. The label has nothing on dogs or cats, so ask the vet what to watch for and when to call.

How do I store it?

The label says not to store the tablets above 86°F and to protect them from moisture. It tells the pharmacist to dispense them in a tight container, so keep them in it with the cap on.

What do I do with leftovers?

The FDA says the best way to get rid of most unused or expired medicines is a take-back option: a drug take-back location, which can be at a pharmacy or a police station, or a prepaid mail-back envelope. If you cannot use one and the medicine is not on the FDA's flush list, the FDA says to mix it, uncrushed, with something unappealing such as dirt, cat litter or used coffee grounds and to seal the mixture in a plastic bag before throwing it away. Flushing is only for medicines on that list, such as opioids. Do not give leftovers to another pet.

My vet's instructions

Write the dose, the times and the stop date here, then print this page for the fridge.

Dose and times: _____________________________________________

Stop date: _____________________________________________

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